Comparative effectiveness research using observational data: Active comparators to emulate target trials with inactive comparators

Published in eGEMs, 2016

Recommended citation: Huitfeldt A, Hernan MA, Kalager M, Robins JM. "Comparative effectiveness research using observational data: Active comparators to emulate target trials with inactive comparators". eGEMs: Vol. 4: Iss. 1, Article 20. http://ahuitfeldt.github.io/files/paper2.pdf

This paper contributes to the theory of active comparators in clinical research. We discuss attempts to minimize bias in observational studies by using a comparator group consisting of individuals who initiate a drug unrelated to the outcome of interest, and clarify the conditions under which this approach leads to valid inferences.

Recommended citation: ‘Huitfeldt A, Hernan MA, Kalager M, Robins JM. "Comparative effectiveness research using observational data: Active comparators to emulate target trials with inactive comparators". eGEMs: Vol. 4: Iss. 1, Article 20.’